These combinations are considered extremely harmful and should always be avoided.
amt
maois
opioids
tramadol
Cocaine
Aliases: coke
Categories
Summary
A highly popular, short acting CNS stimulant that works by blocking the reuptake of dopamine, serotonin, and norepinephrine. It is known to increase euphoria, confidence, sex-drive, focus, body temperature, and heart rate. Cocaine can cause severe vasoconstriction and is known to be cardiotoxic and have a high potential for compulsive redosing and addiction.
Dose Information
Onset, Duration & After-effects
- Duration:
- 1-1.5 hours
- After-effects:
- 1-4 hours
Effects
- Elevated mood
- Increase in irritability
- hyper-inflated ego
- euphoria
- stimulation
- raised heartrate
- numbing effects depending on ROA
- nausea (particularly at high doses)
Helpful Links
Known Combinations
Studies & References
- Rhabdomyolysis associated with cocaine abuse. -https://www.ncbi.nlm.nih.gov/pubmed/1743698
- Rhabdomyolysis associated with cocaine abuse.
- The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, a...
- Effects of concurrent use of alcohol and cocaine.
- Cocaine-like neurochemical effects of antihistaminic medications.
- Cocaine cardiotoxicity: a review of the pathophysiology, pathology, and treatment options.
- Citalopram enhances cocaine's subjective effects in rats.
- Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias.
- High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory.
- The effects of combinations of intranasal cocaine, smoked marijuana, and task performance on heart rate and blood pressure.
- Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats.
- Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.
- Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-ind...
- Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects.
- Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.
- Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefronta...
- Cocaine tolerance and cross-tolerance.
- Cocaethylene is as cardiotoxic as cocaine but is less toxic than cocaine plus ethanol.
- Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline.
- Cocaine contamination of United States paper currency.
- A study suggests that having a history of cocaine and poly drug abuse can lead to acute open-angle glaucoma
- using cocaine while pregnant is dangerous for the fetus's health