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    Summary

    A South African plant containing numerous psychoactive alkaloids, including mesembrine and mesembrenone. The first written account of the substance was in 1662. The pharmacology of these compounds is poorly understood, but they are suspected to be serotonin uptake inhibitors and potentially monoamine releasers. Said to suppress appetite, produce mild euphoria and reduce anxiety.

    ⚠️ AVOID: Other CNS depressants.

    Dose Information

    Onset, Duration & After-effects

    • Onset:
      • Oral: 30-90 minutes
      • Insufflated: 5-10 minutes
      • Smoked: 1-2 minutes
    • Duration:
      • Insufflated: 60-150 minutes
      • Oral: 180-360 minutes
      • Vapourized: 90-150 minutes
    • After-effects:
      • 1-8 hours

    Helpful Links

    Known Combinations

    No interaction data available from Tripsit

    Studies & References