These combinations are considered extremely harmful and should always be avoided.
alcohol
ghb/gbl
opioids
tramadol
Ketamine
Aliases: k, ket, kitty, kittens
Categories
Summary
A short acting dissociative anaesthetic and hallucinogen commonly used in emergency medicine. It is the prototypical dissociative, and is widely used at sub-anesthetic doses recreationally. Small doses are comparable with alcohol, while larger doses are immobilising and lead to psychedelic experiences: the "K-Hole."
Dose Information
Onset, Duration & After-effects
- Onset:
- Insufflated: 7.5-20 minutes
- Intramuscular: 2-7.5 minutes
- Intravenous: 0-2 minutes
- Oral: 10-75 minutes
- Duration:
- 1-2 hours
- After-effects:
- 1-2 hours
Effects
- A feeling of drunkenness and well being at low doses
- As dose increases the user may begin to feel a disconnection from their body
- At 'khole' doses the user may become completely disconnected from both body and mind
Helpful Links
Known Combinations
Studies & References
- Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model ps..
- The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations
- Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome
- Effects of ketamine on precipitated opiate withdrawal
- Low-dose ketamine with multimodal postcesarean delivery analgesia: a randomized controlled trial
- Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys
- GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects
- From "Special K" to "Special M": the evolution of the recreational use of ketamine and methoxetamine
- Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial
- Brain damages in ketamine addicts as revealed by magnetic resonance imaging
- Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
- Are sexes affected differently by ketamine? An exploratory study in ketamine users
- Therapeutic infusions of ketamine: do the psychoactive effects matter
- The absolute bioavailability of racemic ketamine from a novel sublingual formulation
- The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model..
- The promise of ketamine for treatment-resistant depression: current evidence and future directions
- Antidepressants do not increase the lethality of ketamine in mice
- Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain
- Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children
- Tissue distribution of ketamine in a mixed drug fatality
- [From the racemate to the eutomer: (S)-ketamine. Renaissance of a substance?]
- Chronic abuse has led to a case of kidney and liver damage http://www.ncbi.nlm.nih.gov/pubmed/24982568
- ketamine in the hospital setting can raise blood pressure and is something to be considered when using it: "Emergency care in the streets"
- Ketamine shows promise in treating suicidal ideation in patients with depression