Oxycodone
Aliases: oxy, oxycontin, percocet, oxynorm
Categories
Summary
A semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids.
Dose Information
Onset, Duration & After-effects
- Onset:
- Insufflated: 2-5 minutes
- Intravenous: 0-1 minutes
- Oral_er: 40 minutes
- Oral_ir: 20 minutes
- Duration:
- Oral_er: 6-8 hours
- Insufflated: 3-5 hours
- Intravenous: 3-5 hours
- Oral_ir: 4-6 hours
- After-effects:
- 1-24 hours
Effects
- Pain relief
- Respiratory depression
- Sedation
- Constipation
- Cough suppression
- Decreased libido
- Difficulty urinating
- Itchiness
- Nausea
- Pupil constriction
- Stomach cramps
- Appetite suppression
- Euphoria
- Anxiety suppression
- Dream potentiation
Helpful Links
Known Combinations
Studies & References
- Controlled-release oxycodone-induced seizures.
- Grapefruit juice enhances the exposure to oral oxycodone.
- Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.
- Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain.
- Differential effects of food on the bioavailability of controlled-release oxycodone tablets and immediate-release oxycodone solution.
- Oxycodone is found to suppress sodium currents in the thalamic regions of the brain at high doses and is an effect that is independent of the MOR/u-opioid recepter and therefore this mechanism is not blocked by the use of naloxone
- Oxycodone is found to have longer lasting more efficient effects on pain due to neuropathy because of having GABA-B agonist properties -http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091297
- Oxycodone when paired with an ultra low dose of naltrexone, an opioid antagonist, oxycodone has a longer duration of pain relief
- Oxycodone has been found to be an effective treatment for restless leg syndrome
- Pharmacokinetics of oxycodone done orally and intramuscularly http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1992.tb04090.x/abstract