These combinations are considered extremely harmful and should always be avoided.
alcohol
amphetamines
amt
benzodiazepines
cocaine
dextromethorphan
ghb/gbl
ketamine
lithium
maois
mdma
mxe
opioids
pcp
ssris
Aliases: tram
A synthetic opioid analgesic, tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.
These combinations are considered extremely harmful and should always be avoided.